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Levels of <t> proinflammatory </t> cytokines in CSF and plasma by treatment arm
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HU- MCA-13 induced neurotropic effect in different neuronal cultures. Neurotropic effect was measured after treatment with 5 μM of HU-MCA-13 of rat PC12 dopaminergic neurons (7 days, top row), mice dorsal root ganglion (DRG) explants (5 days, middle row) and rat spinal cord sensory neurons (14 days, bottom row). The negative control cultures were treated with 0.1% DMSO and the positive control cultures were treated with 50 ng/mL mouse <t>β-nerve</t> <t>growth</t> <t>factor</t> <t>(NGF)</t> for the same periods of time.
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HU- MCA-13 induced neurotropic effect in different neuronal cultures. Neurotropic effect was measured after treatment with 5 μM of HU-MCA-13 of rat PC12 dopaminergic neurons (7 days, top row), mice dorsal root ganglion (DRG) explants (5 days, middle row) and rat spinal cord sensory neurons (14 days, bottom row). The negative control cultures were treated with 0.1% DMSO and the positive control cultures were treated with 50 ng/mL mouse <t>β-nerve</t> <t>growth</t> <t>factor</t> <t>(NGF)</t> for the same periods of time.
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HU- MCA-13 induced neurotropic effect in different neuronal cultures. Neurotropic effect was measured after treatment with 5 μM of HU-MCA-13 of rat PC12 dopaminergic neurons (7 days, top row), mice dorsal root ganglion (DRG) explants (5 days, middle row) and rat spinal cord sensory neurons (14 days, bottom row). The negative control cultures were treated with 0.1% DMSO and the positive control cultures were treated with 50 ng/mL mouse <t>β-nerve</t> <t>growth</t> <t>factor</t> <t>(NGF)</t> for the same periods of time.
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HU- MCA-13 induced neurotropic effect in different neuronal cultures. Neurotropic effect was measured after treatment with 5 μM of HU-MCA-13 of rat PC12 dopaminergic neurons (7 days, top row), mice dorsal root ganglion (DRG) explants (5 days, middle row) and rat spinal cord sensory neurons (14 days, bottom row). The negative control cultures were treated with 0.1% DMSO and the positive control cultures were treated with 50 ng/mL mouse <t>β-nerve</t> <t>growth</t> <t>factor</t> <t>(NGF)</t> for the same periods of time.
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HU- MCA-13 induced neurotropic effect in different neuronal cultures. Neurotropic effect was measured after treatment with 5 μM of HU-MCA-13 of rat PC12 dopaminergic neurons (7 days, top row), mice dorsal root ganglion (DRG) explants (5 days, middle row) and rat spinal cord sensory neurons (14 days, bottom row). The negative control cultures were treated with 0.1% DMSO and the positive control cultures were treated with 50 ng/mL mouse <t>β-nerve</t> <t>growth</t> <t>factor</t> <t>(NGF)</t> for the same periods of time.
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HU- MCA-13 induced neurotropic effect in different neuronal cultures. Neurotropic effect was measured after treatment with 5 μM of HU-MCA-13 of rat PC12 dopaminergic neurons (7 days, top row), mice dorsal root ganglion (DRG) explants (5 days, middle row) and rat spinal cord sensory neurons (14 days, bottom row). The negative control cultures were treated with 0.1% DMSO and the positive control cultures were treated with 50 ng/mL mouse <t>β-nerve</t> <t>growth</t> <t>factor</t> <t>(NGF)</t> for the same periods of time.
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HU- MCA-13 induced neurotropic effect in different neuronal cultures. Neurotropic effect was measured after treatment with 5 μM of HU-MCA-13 of rat PC12 dopaminergic neurons (7 days, top row), mice dorsal root ganglion (DRG) explants (5 days, middle row) and rat spinal cord sensory neurons (14 days, bottom row). The negative control cultures were treated with 0.1% DMSO and the positive control cultures were treated with 50 ng/mL mouse <t>β-nerve</t> <t>growth</t> <t>factor</t> <t>(NGF)</t> for the same periods of time.
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HU- MCA-13 induced neurotropic effect in different neuronal cultures. Neurotropic effect was measured after treatment with 5 μM of HU-MCA-13 of rat PC12 dopaminergic neurons (7 days, top row), mice dorsal root ganglion (DRG) explants (5 days, middle row) and rat spinal cord sensory neurons (14 days, bottom row). The negative control cultures were treated with 0.1% DMSO and the positive control cultures were treated with 50 ng/mL mouse <t>β-nerve</t> <t>growth</t> <t>factor</t> <t>(NGF)</t> for the same periods of time.
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Image Search Results


Levels of  proinflammatory  cytokines in CSF and plasma by treatment arm

Journal: Psychopharmacology

Article Title: Assessment of pioglitazone and proinflammatory cytokines during buprenorphine taper in patients with opioid use disorder

doi: 10.1007/s00213-018-4986-5

Figure Lengend Snippet: Levels of proinflammatory cytokines in CSF and plasma by treatment arm

Article Snippet: Plasma and CSF samples were analyzed in duplicate with MesoScale V-PLEX Plus (Meso Scale Discovery, MSD) Custom Proinflammatory Panel 1(IL-1β, IL-6, Il-10, TNF-α) and Custom Chemokine Panel 1 (MCP-1).

Techniques: Clinical Proteomics

HU- MCA-13 induced neurotropic effect in different neuronal cultures. Neurotropic effect was measured after treatment with 5 μM of HU-MCA-13 of rat PC12 dopaminergic neurons (7 days, top row), mice dorsal root ganglion (DRG) explants (5 days, middle row) and rat spinal cord sensory neurons (14 days, bottom row). The negative control cultures were treated with 0.1% DMSO and the positive control cultures were treated with 50 ng/mL mouse β-nerve growth factor (NGF) for the same periods of time.

Journal: ACS Chemical Neuroscience

Article Title: Neurotropic activity and safety of methylene-cycloalkylacetate (MCA) derivative 3-(3-allyl-2-methylenecyclohexyl) propanoic acid

doi: 10.1021/acschemneuro.0c00255

Figure Lengend Snippet: HU- MCA-13 induced neurotropic effect in different neuronal cultures. Neurotropic effect was measured after treatment with 5 μM of HU-MCA-13 of rat PC12 dopaminergic neurons (7 days, top row), mice dorsal root ganglion (DRG) explants (5 days, middle row) and rat spinal cord sensory neurons (14 days, bottom row). The negative control cultures were treated with 0.1% DMSO and the positive control cultures were treated with 50 ng/mL mouse β-nerve growth factor (NGF) for the same periods of time.

Article Snippet: Tissue culture grade mouse β-NGF, was purchased from Alomone Laboratories (Jerusalem, Israel).

Techniques: Negative Control, Positive Control